HLA-G (Major Histocompatibility Complex; class I; G) Antibody
Product Sizes
100 ug
£671.00
3135-MSM5-P1ABX-100UG
About this Product
- SKU:
- 3135-MSM5-P1ABX
- Additional Names:
- HLA G antigen | MHC class I antigen G
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- HLAG/7095
- Clonality:
- Monoclonal
- Extra Details:
- Major histocompatibility complex (MHC); human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains; an a or heavy chain; and a non-covalently associated protein; β2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells; HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human HLAG protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 39kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133565
