HLA-E (Major histocompatibility complex; class I; E) Antibody
Product Sizes
20 ug
£364.00
3133-MSM5-P0-20UG
About this Product
- SKU:
- 3133-MSM5-P0
- Additional Names:
- MHC class I antigen E; MHC class Ib antigen; non-classical MHC class I antigen; nonclassical MHC class I antigen
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- HLAE/13125
- Clonality:
- Monoclonal
- Extra Details:
- HLA-E Antibody (3H2679) is an IgG1 κ mouse monoclonal HLA-E antibody (also designated HLA major histocompatibility complex; class I; E antibody; human leukocyte antigen (HLA) E antibody; 45 kDa transmembrane class I human leukocyte antigen E antibody; chromosome 6p22 gene complex class 1E antibody; or natural killer cell (NK) expansion marker antibody) that detects the HLA-E protein of human origin by WB; IP; IF and IHC(P). HLA-E Antibody (3H2679) is available as the non-conjugated anti-HLA-E antibody. Major histocompatibility complex (MHC) molecules; which include human leukocyte antigens (HLAs); form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). MHC class I molecules consist of two polypeptide chains; an a or heavy chain and a non-covalently associated protein; b-2-Microglobulin. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-A is a MHC class I heavy chain molecule that plays a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and HLA-C are proteins encoded by closely related genes that also exist in the MHC class I. HLA-E belongs to the HLA class I heavy chain paralogs. HLA-E is a heterodimer consisting of a heavy chain and a light chain. The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-150) of human HLAE protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Research Area:
- Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=145023
