HLA-DRB (MHC II) Antibody
Product Sizes
20 ug
£364.00
3123-MSM3-P0-20UG
About this Product
- SKU:
- 3123-MSM3-P0
- Additional Names:
- Human leukocyte antigen DRB1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- L243
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with the HLA-DRB1 antigen; a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR; which depends on the correct folding of the heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody; and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells; activated T-cells; monocytes/macrophages; dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules; HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
- Host:
- Mouse
- Immunogen:
- Activated human peripheral blood mononuclear cells
- Isotype:
- IgG2a
- Molecular Weight:
- ~28kDa (beta chain)
- Research Area:
- Cardiovascular; Cytokine Signaling; Dendritic Cell Marker; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115532
