HLA-DR (MHC II) Antibody
Product Sizes
100 ug
£671.00
3122-MSM4-P1-100UG
About this Product
- SKU:
- 3122-MSM4-P1
- Additional Names:
- MHC class II antigen DRA
- Application:
- Flow Cytometry, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- TAL 1B5
- Clonality:
- Monoclonal
- Extra Details:
- Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO; and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells; HLA-DM; -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR; -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain ( -Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
- Host:
- Mouse
- Isotype:
- IgG1
- Molecular Weight:
- 36kDa (alpha chain); 27kDa (beta chain); 63kDa (HLA-DR dimer)
- Research Area:
- B Cell Markers; Cardiovascular; Cytokine Signaling; Dendritic Cell Marker; Hematopoietic Stem Cells; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115503
