HLA-DRA (MHC II) Antibody
Product Sizes
20 ug
£364.00
3122-MSM1-P0-20UG
About this Product
- SKU:
- 3122-MSM1-P0
- Additional Names:
- MHC class II antigen DRA
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- IPO-10
- Clonality:
- Monoclonal
- Extra Details:
- MAb IPO-10 defines the antigen; which appears on B cell progenitors following HLA-DR and preceding CD10; CD19; CD22; CD37 and cym. It is expressed on resting B cells and than reappears and persists in cytoplasm and on cell surface until cytoplasmic Ig appears. It is a useful antibody for diagnostics of neoplasms of B cell origins. It reacts with human B cell lines Daudi; Raji; Namalva; EB-3; RPMI-8226 (50% of cells). The MAb does not label T cell lines; blood granulocytes; thymocytes or bone marrow stromal fibroblasts. No significant changes are detected after PHA or ConA stimulation while LPS and PWM stimulated cultures after 18-48h show decreased number of antigen-positive cells but in final terms of cultivation antigen is expressed again. This MAb labels B cell leukemias and some lymphomas. Hairy cell leukemia strongly reacts and 70% of B cell CLL and some B-NHL were also positive. IPO-10 reacts with AMML cells and in a majority of Hodgkin's disease cases a significant percentage of affected lymph node cells were detected. '
- Host:
- Mouse
- Immunogen:
- Spleen cells of a patient with hairy cell leukemia (Daudi cells)
- Isotype:
- IgG3
- Molecular Weight:
- 36kDa
- Research Area:
- B Cell Markers; Cardiovascular; Cytokine Signaling; Dendritic Cell Marker; Hematopoietic Stem Cells; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115477
