HLA-DQ (MHC II) Antibody
Product Sizes
20 ug
£364.00
3117-MSM1-P0-20UG
About this Product
- SKU:
- 3117-MSM1-P0
- Additional Names:
- DC-1 alpha chain | DC-alpha | HLA-DCA | MHC class II DQA1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- SPV-L3
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a DQ antigen; which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB); both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes; dendritic cells; macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities; resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
- Host:
- Mouse
- Immunogen:
- T4-positive CTL clone HG-38
- Isotype:
- IgG2a
- Molecular Weight:
- 60kDa
- Research Area:
- Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115473
