HIF1 alpha (Hypoxia-Inducible Factor 1-alpha) Antibody
Product Sizes
100 ug
£671.00
3091-MSM1-P1-100UG
About this Product
- SKU:
- 3091-MSM1-P1
- Additional Names:
- ARNT-interacting protein | Basic-helix-loop-helix-PAS protein MOP1 | Class E basic helix-loop-helix protein 78 | Member of PAS protein 1 | PAS domain-containing protein 8
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- HIF1A/84
- Clonality:
- Monoclonal
- Extra Details:
- HIF1 (hypoxia-inducible factor 1); a heterodimeric transcription factor complex central to cellular response to hypoxia; consists of two subunits (HIF-1 alpha and HIF-1 beta) which are basic helix-loop-helix proteins of the PAS (Per; ARNT; Sim) family. Expression of HIF-1 alpha protein is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway); growth factors; oncogenic activation; or loss of tumor suppressor function etc. In normoxic cells; HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine; cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells; whereas; contrastingly; HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response; HIF1s regulates the transcription of genes responsible for angiogenesis; erythropoiesis/iron-metabolism; glucose metabolism; cell proliferation/survival; adipogenesis; carotid body formation; B lymphocyte development and immune reactions.
- Host:
- Mouse
- Immunogen:
- Recombinant human HIF1 alpha protein
- Isotype:
- IgG2b
- Molecular Weight:
- 92-110kDa
- Research Area:
- Angiogenesis; Cancer; Cardiovascular; Cytokine Signaling; Hypoxia; Immunology; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115411
