HEXB Antibody
Product Sizes
100 ug
£671.00
3074-MSM2-P1-100UG
About this Product
- SKU:
- 3074-MSM2-P1
- Additional Names:
- Beta-N-acetylhexosaminidase subunit beta | Cervical cancer proto-oncogene 7 protein | N-acetyl-beta-glucosaminidase subunit beta
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- HEXB/7762
- Clonality:
- Monoclonal
- Extra Details:
- Hexosaminidase B (HEXB); also designated β-hexosaminidase B; is a hexosaminidase B (HEXB); also designated β-hexosaminidase B; is a tetramer of two β-A and two β-B chains and is found in the lysosomes of cells. Sandhoff disease (SD); also known as GM2-gangliosidosis type II; is caused by mutations in the HEXB gene that affect the β subunit. These mutations disrupt the activity of HEXB and HEXA; which prevents the breakdown of GM2 ganglioside; a fatty material found in the brain; therby rendering both the HEXA and HEXB enzymes deficient. SD is a rare autosomal recessive disorder characterized by an accumulation of GM2 ganglioside; which causes progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease; which is caused by mutations in the HEXA gene; although SD is more severe.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment human HEXB protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 63kDa
- Research Area:
- Cardiovascular; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133509
