T-bet / Tbox-bet / TBX21 Antibody
Product Sizes
20 ug
£364.00
30009-MSM2-P0-20UG
About this Product
- SKU:
- 30009-MSM2-P0
- Additional Names:
- T-cell-specific T-box transcription factor T-bet | Transcription factor TBLYM
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TBX21/6724
- Clonality:
- Monoclonal
- Extra Details:
- T helper (Th) lymphocytes differentiate into two unique subsets; Th1 and Th2; which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset; and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine; IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells; and in increased levels in stimulated AE7.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 1-200) of human TBX21 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 62kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131543
