Recombinant MSH6 (DNA Mismatch Repair Protein) Antibody
Product Sizes
20 ug
£364.00
2956-RBM22-P0-20UG
About this Product
- SKU:
- 2956-RBM22-P0
- Additional Names:
- G/T mismatch-binding protein | MutS protein homolog 6 | MutS-alpha 160 kDa subunit
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MSH6/8338R
- Clonality:
- Monoclonal
- Extra Details:
- MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch; that occur during DNA replication. Loss of MSH6 expression leads to an accumulation of DNA replication errors in the proliferating cells; particularly in areas of the genome with short repetitive nucleotide sequences; a phenomenon known as microsatellite instability (MSI). MSH6 always used as panel with MLH1; MSH2; PMS2; and may be useful to aid in identifying the most probable gene responsiblefor the MSI.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 1-200) of human MSH6 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 163kDa
- Research Area:
- Colon Cancer; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133482
