Recombinant MSH6 (DNA Mismatch Repair Protein) Antibody
Product Sizes
100 ug
£671.00
2956-RBM18-P1-100UG
About this Product
- SKU:
- 2956-RBM18-P1
- Additional Names:
- G/T mismatch-binding protein | MutS protein homolog 6 | MutS-alpha 160 kDa subunit
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- MSH6/7065R
- Clonality:
- Monoclonal
- Extra Details:
- The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially; inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family; GTBP (also designated MSH6); is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human MSH6 protein (around aa 374-540) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 163kDa
- Research Area:
- Colon Cancer; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115203
