PD-L1 / PDCD1LG1 / CD274 / B7-H1 (Cancer Immunotherapy Target) Antibody
Product Sizes
20 ug
£364.00
29126-MSM4-P0-20UG
About this Product
- SKU:
- 29126-MSM4-P0
- Additional Names:
- B7 homolog 1
- Application:
- ELISA, Western Blot
- translate.label.attr.clone:
- PDL1/2744
- Clonality:
- Monoclonal
- Extra Details:
- Engagement of CD28 by B7-1 (CD80) or B7-2 (CD86) in the presence of antigen promotes T-cell proliferation; cytokine production; differentiation of effector T-cells and the induction of BCLX; a promoter of T-cell survival. Engagement of CTLA4 by B7-1 or B7-2; on the other hand; may inhibit proliferation and interleukin-2 (IL-2) production. PD-L1 is 290-amino acid type I transmembrane protein; which is 20% and 15% identical to B7-1 and B7-2; respectively; has immunoglobulin V-like and C-like domains and a 30-amino acid cytoplasmic tail. PD-L1 does not bind CD28; cytotoxic T-lymphocyte A4 or ICOS (inducible co-stimulator). IL-2; although produced in small amounts; is required for the effect of PD-L1 co-stimulation. PD-L2 protein contains a signal sequence; IgV- and IgC-like domains; a transmembrane region and a cytoplasmic region. The constitutive expression of PD-L1 and PD-L2 on parenchymal cells of heart; lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human CD274 protein (around aa39-191) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 37-50kDa
- Research Area:
- Immunology; Mast Cell Marker; PD-1 blockade immunotherapy; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115115
