CD13 / Aminopeptidase-N (Myeloid Cell Marker) Antibody
Product Sizes
100 ug
£671.00
290-MSM7-P1-100UG
About this Product
- SKU:
- 290-MSM7-P1
- Additional Names:
- Alanyl aminopeptidase | Aminopeptidase M | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | gp150
- Application:
- ELISA, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- APN/6997
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes an integral membrane glycoprotein of 150kDa; identified as CD13 (also known as aminopeptidase-N). The antibody recognizes an extracellular epitope. The CD13 antigen is present on most cells of myeloid origin including granulocytes; monocytes; mast cells; and GM-progenitor cells. It is also expressed by the majority of AML; CML in myeloid blast crisis; and in a smaller fraction of lymphoid leukemias. CD13 is absent from normal lymphocytes; platelets and erythrocytes. CD13 is also present on fibroblasts; endothelial cells; epithelial cells from renal proximal tubules and intestinal brush border; bone marrow stromal cells; osteoclasts; and cells lining bile duct canaliculi. CD13 is identical to aminopeptidase N (APN); a prominent membrane-bound metalloprotease present on the surface of intestinal brush border and renal tubules. CD13 plays a role in metabolism of biologically active peptides; in phagocytosis; and in bactericidal / tumoricidal activities. It also serves as a receptor for human coronaviruses (HCV). The lineage-restricted pattern of expression of CD13 within the hemopoietic compartment suggests that it may be important in myeloid cell differentiation.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa50-250) of human ANPEP protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 150kDa
- Research Area:
- Cardiovascular; Hematopoietic Stem Cells; Immunology; Neuroscience
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=115081
