Blood Group Antigen A (CD173) Antibody
Product Sizes
100 ug
£671.00
28-MSM4-P1-100UG
About this Product
- SKU:
- 28-MSM4-P1
- Additional Names:
- Fucosylglycoprotein 3-alpha-galactosyltransferase | Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase | Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase | Glycoprotein-fucosylgalactoside alpha-galactosyltransferase | Histo-blood group A transferase | Histo-blood group B transferase | NAGAT
- Application:
- Immunofluorescence
- translate.label.attr.clone:
- HE-14
- Clonality:
- Monoclonal
- Extra Details:
- This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1; 2; 3; 4; 5; 6) and Forssmann antigen. It is also reactive with the immuno-dominant A trisaccharide. Blood group antigen expression in human colon cancer was studied by means of two monoclonal antibodies of broad anti-A (HE-14) and anti-type 3 and type 4 chain-based A and H (HE-10) specificity. These antigens were proved to re-appear in tumors of the distal colon; the HE-10 antibody reacting more frequently (9 out of 12 samples) than HE-14 (5 out of 12 samples) and frequently with supra-nuclear staining of the cytoplasm probably in those places of the Golgi apparatus where carbohydrate antigens are synthesized. This staining pattern is characteristic of HE-10 in normal colonic mucosa as well. With HE-14; staining was often absent in less differentiated tumors; while HE-10 did react in such tumors. In some cases; these two antibodies gave different staining patterns in parallel sections from the same tissue sample; primarily at the cellular level. Three out of 12 cases showed blood group antigen expression in the mucosa of the distal colon adjacent to the tumor only when HE-10 Ab was used.
- Host:
- Mouse
- Immunogen:
- Mixture of erythrocytes of blood group A1and glycoprotein fraction isolated from the saliva of secretors with blood group A
- Isotype:
- IgM
- Molecular Weight:
- Multiple
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114993
