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Antibodies

Anti Mullerian Hormone (AMH) / Mullerian Inhibiting Substance (MIS) Antibody

Product Sizes
100 ug
£671.00
268-MSM1-P1ABX-100UG
About this Product
SKU:
268-MSM1-P1ABX
Additional Names:
Anti-Muellerian hormone | Muellerian-inhibiting substance
Application:
Immunohistochemistry, Western Blot
translate.label.attr.clone:
AMH/300
Clonality:
Monoclonal
Extra Details:
The transforming growth factor 尾(TGF尾) superfamily is composed of numerous growth and differentiation factors; including TGF尾1-3; Mullerian inhibiting substance (MIS); growth/differentiation factor (GDF) 1-9; bone morphogenic protein (BMP) 2-8; glial cell line-derived neurotrophic factor (GDNF); Inhibin 伪;尾-A; 尾-B and 尾-C; Lefty and Nodal. Members of the TGF尾superfamily are involved in embryonic development and adult tissue homeostasis. The MIS glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIS and testosterone; the presence of which result in male offspring. Absence of MIS and testosterone in a developing fetus results in the induction of Mullerian duct differentiation; and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIS causes regression of the Muellerian duct. MIS inhibits the growth of tumors derived from tissues of Mullerian duct origin. MIS can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Host:
Mouse
Immunogen:
Recombinant fragment of the C-terminus of human AMH (aa 460-560) (exact sequence is proprietary)
Isotype:
IgG1
Molecular Weight:
70kDa (reduced); 140kDa (nonreduced)
Research Area:
Developmental Biology; Signal Transduction
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody