EMI1 (Early Mitotic Inhibitor-1) Antibody
Product Sizes
20 ug
£364.00
26271-MSM1-P0-20UG
About this Product
- SKU:
- 26271-MSM1-P0
- Additional Names:
- Early mitotic inhibitor 1
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- EMI1/1176
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a 56kDa protein; which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition; Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (203 amino acid residues between aa 1-250) of human EMI1 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 56kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114721
