AMBP (Alpha 1 Microglobulin) / Bikunin Antibody
Product Sizes
100 ug
£671.00
259-MSM6-P1-100UG
About this Product
- SKU:
- 259-MSM6-P1
- Additional Names:
- Protein HC | Alpha-1 microglycoprotein | Complex-forming glycoprotein heterogeneous in charge | Bikunin | EDC1 | HI-30 | Uronic-acid-rich protein
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- AMBP/4536
- Clonality:
- Monoclonal
- Extra Details:
- The AMBP (α-1-Microglobulin/Bikunin precursor) gene encodes a protein precursor; known as AMBP; that is cleaved to produce two distinct proteins; designated α-1-Microglobulin and Bikunin. α-1-Microglobulin; also known as protein HC; is a member of the lipocalin superfamily and is secreted mainly in plasma; urine and cerebrospinal fluid. Thought to have reductase/dehydrogenase activity; α-1-Microglobulin exhibits immunosuppressive properties; such as cytokine secretion and inhibition of antigen-induced lymphocyte cell proliferation; and may be involved in the reduction of biological pro-oxidants. The second protein cleavage product; designated Bikunin and also known as inter-α-trypsin inhibitor light chain; ITI-LC or urinary trypsin inhibitor; is a widely expressed protein that is stored in the granules of human connective tissue mast cells. One of many proteins in the Kunitz-type protease inhibitor family; Bikunin prevents autodigestion by exocrine enzymes; such as trypsinogen and chymo-trypsinogen; and plays a role in the antiinflammatory/antiproteinase immune response. Unlike α-1-Microglobulin; Bikunin is implicated in the pathogenesis of a number of renal diseases; such as urolithiasis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa200-353) of human AMBP protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 30kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133280
