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Antibodies

Kallikrein 5 (KLK5) Antibody

Product Sizes
20 ug
£364.00
25818-MSM21-P0-20UG
About this Product
SKU:
25818-MSM21-P0
Additional Names:
Kallikrein-like protein 2 | Stratum corneum tryptic enzyme
Application:
Immunohistochemistry
translate.label.attr.clone:
KLK5/4761
Clonality:
Monoclonal
Extra Details:
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme; which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown; but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins; the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4; KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2; tissue kallikrein; or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them; specifically KLK3; KLK6 and KLK10; are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin; mammary gland and testis.
Host:
Mouse
Immunogen:
Recombinant fragment of human KLK5 protein (around aa 1-200) (exact sequence is proprietary)
Isotype:
IgG1
Molecular Weight:
33kDa
Research Area:
Developmental Biology
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody