Recombinant Ferritin; Heavy Chain (FTH) (Microglia Marker) Antibody
Product Sizes
100 ug
£671.00
2495-RBM6-P1ABX-100UG
About this Product
- SKU:
- 2495-RBM6-P1ABX
- Additional Names:
- Cell proliferation-inducing gene 15 protein
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- FTH/8700R
- Clonality:
- Monoclonal
- Extra Details:
- Mammalian ferritins consist of 24 subunits made up of 2 types of poly-peptide chains; ferritin heavy chain and ferritin light chain; which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage; the oxidationof FeI(II); whereas ferritin light chains promote the nucleation of ferrihydrite; enabling storage of Fe(III). The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering; heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase; which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms: hereditary hyperferritinemia cataract syndrome; in which light chain ferritin is overexpressed; and oxidative stress; an important factor in the development of aging-related cataracts.
- Host:
- Rabbit
- Immunogen:
- Recombinant human FTH1 protein fragment (around aa 58-180) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 21kDa
- Research Area:
- Cardiovascular; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127697
