Recombinant ALK (Anaplastic Lymphoma Kinase) / CD246 Antibody
Product Sizes
20 ug
£364.00
238-MSM7-P0-20UG
About this Product
- SKU:
- 238-MSM7-P0
- Additional Names:
- Anaplastic lymphoma kinase
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rALK1/1504
- Clonality:
- Monoclonal
- Extra Details:
- The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons; and a few endothelial cells and pericytes. The hybrid gene;NPM-ALK; created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein; nucleophosmin (NPM); joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence; the ALK gene comes under the control of the NPM promoter; which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene; resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly; expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
- Host:
- Mouse
- Immunogen:
- Recombinant human ALK protein fragment (aa200-335)
- Isotype:
- IgG1
- Molecular Weight:
- 80kDa (hybrid); 200kDa (wild type)
- Research Area:
- AKT Signaling; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114363
