Recombinant PRAME nuclear receptor transcriptional regulator Antibody
Product Sizes
100 ug
£671.00
23532-RBM4-P1BX-100UG
About this Product
- SKU:
- 23532-RBM4-P1BX
- Additional Names:
- Opa-interacting protein 4 | Preferentially expressed antigen of melanoma
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PRAME/6928R
- Clonality:
- Monoclonal
- Extra Details:
- Functions as a transcriptional repressor; inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA; RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest; differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues; except testis. The encoded protein acts as a repressor of retinoic acid receptor; and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa100-509) of human PRAME protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 58kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. ;Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128240
