Recombinant Folate Receptor Alpha (FRalpha) / FOLR1 Antibody
Product Sizes
100 ug
£671.00
2348-RBM5-P1ABX-100UG
About this Product
- SKU:
- 2348-RBM5-P1ABX
- Additional Names:
- Adult folate-binding protein (FBP) | Folate receptor 1 | Folate receptor; adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- FOLR1/13424R
- Clonality:
- Monoclonal
- Extra Details:
- Folate receptor alpha (FRα) is a membrane-bound protein that facilitates high-affinity folate transport; essential for cell metabolism; DNA synthesis; and repair; particularly in rapidly dividing cancer cells with increased folate demands. This receptor; encoded by the FOLR1 gene; employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FRα expression correlates with tumor stage and grade; suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels; homocysteine accumulation; hormones; transcription factors; and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FRα in tumors and its association with aggressive cancer phenotypes; FRα is a valuable marker for studying tumor biology and progression; particularly in epithelial cancers.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1-200) of human FOLR1 protein corresponding to the extracellular domain (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 29kDa
- Research Area:
- Immuno Oncology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=144406
