Recombinant TARDBP TAR DNA binding protein / TDP43 Antibody
Product Sizes
100 ug
£671.00
23435-RBM3-P1ABX-100UG
About this Product
- SKU:
- 23435-RBM3-P1ABX
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- TARDP/9299R
- Clonality:
- Monoclonal
- Extra Details:
- TARDBP (TAR DNA binding protein); also known as TDP-43; is a nuclear protein that contains two RRM (RNA recognition motif) domains. Ubiquitously expressed with highest levels found in placenta; lung; pancreas; spleen and genital tract; TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs; TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. TARDBP can also function as a negative regulator of splicing activity and is known to be involved in the splicing of CFTR (cystic fibrosis transmembrane receptor). In addition; TARDBP is a major component of ubiquitin-positive inclusion bodies that are prominent in many neurodegenerative diseases. This suggests that TARDBP may play a role in the development of neurodegenerative disorders. Due to alternative splicing events; various isoforms exist for TARDBP.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment within human TDP43 aa 200 to the C-terminus.
- Isotype:
- IgG
- Molecular Weight:
- 44kDa
- Research Area:
- Neuroscience; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131476
