Sirtuin1 (SIRT1) Antibody
Product Sizes
20 ug
£364.00
23411-MSM1-P0-20UG
About this Product
- SKU:
- 23411-MSM1-P0
- Additional Names:
- NAD-dependent protein deacylase sirtuin-1 | Regulatory protein SIR2 homolog 1 | SIR2-like protein 1
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-SIRT1-1E11
- Clonality:
- Monoclonal
- Extra Details:
- The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes; including transcriptional regulation; cell cycle progression; DNA damage repair and aging. In S. cerevisiae; Sir2p deacetylates histones in an NAD-dependent manner; which regulates silencing at the telomeric; rDNA and silent matingtype loci. Sir2p is the founding member of a large family; designated sirtuins; which contain a conserved catalytic domain. The human homologs; which include SIRT1-7; are divided into four main branches: SIRT1-3 are class I; SIRT4 is class II; SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues; with high expression in heart; brain and skeletal muscle and low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53; specifically at Lysine 382.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SIRT1protein
- Isotype:
- IgG1
- Molecular Weight:
- 120kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114215
