DBC2 / RHOBTB2 (Tumor Suppressor) Antibody
Product Sizes
20 ug
£364.00
23221-MSM1-P0-20UG
About this Product
- SKU:
- 23221-MSM1-P0
- Additional Names:
- Deleted in breast cancer 2 gene protein | p83
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- DBC2/3361
- Clonality:
- Monoclonal
- Extra Details:
- The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function; including cytoskeletal rearrangement; nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein); also known as RHOBTB2 (Rho-related BTB domain-containing protein 2); is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region; a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue; heart; brain and fetal lung; DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins; such as CUL-3. Additionally; DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions; DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer; suggesting that mutated DBC-2 may play a role in carcinogenesis.
- Host:
- Mouse
- Immunogen:
- Human recombinant RHOBTB2 protein fragment (around aa 554-604) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 83kDa
- Research Area:
- Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114121
