GRAMD4 (Transcription Factor) Antibody
Product Sizes
20 ug
£364.00
23151-MSM1-P0-20UG
About this Product
- SKU:
- 23151-MSM1-P0
- Additional Names:
- Death-inducing protein
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-GRAMD4-1A10
- Clonality:
- Monoclonal
- Extra Details:
- The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22; which houses over 500 genes and is the second smallest human chromosome. GRAMD4; also designated death-inducing protein (DIP); is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway; which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human GRAMD4 protein
- Isotype:
- IgG1
- Molecular Weight:
- 66kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=114094
