Recombinant FLI1 (Ewing s Sarcoma & Endothelial Marker) Antibody
Product Sizes
20 ug
£364.00
2313-RBM13-P0-20UG
About this Product
- SKU:
- 2313-RBM13-P0
- Additional Names:
- Proto-oncogene Fli-1 | Transcription factor ERGB
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- FLI1/8318R
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 51kDa; which is identified as FLI1. This protein; a member of the ETS family of DNA binding transcription factors; is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation; t(11;22)(q24;q12); which results in fusion of EWS to Fli-1; and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas; hemangioendotheliomas; hemangiomas; and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31; CD34; and Factor VIII.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa200-400) of human FLI1 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 51kDa
- Research Area:
- B Cell Markers; Developmental Biology; Endothelial Cell Marker; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128082
