FOXO1 (Forkhead box O1) (Transcription Factor) Antibody
Product Sizes
20 ug
£364.00
2308-MSM2-P0-20UG
About this Product
- SKU:
- 2308-MSM2-P0
- Additional Names:
- Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1A; FOXO1; FKHR
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- FOXO1/9792
- Clonality:
- Monoclonal
- Extra Details:
- FKHR (for forkhead in rhabdomyosarcoma) and FKHRL1 are members of the forkhead family of transcription factors. Transcriptional activation of FKHR proteins is regulated by the serine/threonine kinase Akt1; which phosphorylates FKHRL1 and results in FKHRL1 associating with 14-3-3 proteins and being retained in the cytoplasm. Induction of apoptosis or withdrawal of growth factors stimulates dephosphorylation and nuclear translocation of FKHR proteins; leading to FKHR-induced gene-specific transcriptional activation. FKHR; also designated forkhead box protein O1A (FOXO1); is a ubiquitously expressed protein that shuttles between the cytoplasm and nucleus. Genetic mutations in FKHR genes; including the t(2;13) and t(1;3) translocations; are commonly found in alveolar rhabdomyosarcomas. These translocations result in the fusion of the amino terminus of Pax-3 or Pax-7; including the paired box and homeodomain DNA-binding domains; with the carboxyterminus of FKHR; which contains a transcriptional activation domain. The Pax-3/FKHR fusion protein appears to function as an oncogenic transcription factor that enhances the activation of normal Pax-3 target genes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa450-650) of human FOXO1 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 80kDa
- Research Area:
- Immuno Oncology; Oncology; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=142565
