SIRT2 Antibody
Product Sizes
20 ug
£364.00
22933-MSM2-P0-20UG
About this Product
- SKU:
- 22933-MSM2-P0
- Additional Names:
- NAD-dependent protein defatty-acylase sirtuin-2 | Regulatory protein SIR2 homolog 2 | SIR2-like protein 2
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-SIRT2-1A8
- Clonality:
- Monoclonal
- Extra Details:
- The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes; including transcriptional regulation; cell cycle progression; DNA-damage repair and aging. In S. cerevisiae; Sir2p deacetylates histones in a NAD-dependent manner; which regulates silencing at the telomeric; rDNA and silent mating-type loci. Sir2p is the founding member of a large family; designated sirtuins; which contain a conserved catalytic domain. The human homologs; which include SIRT1-7; are divided into four main branches: SIRT1-3 are class I; SIRT4 is class II; SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SIRT2 protein
- Isotype:
- IgG1
- Molecular Weight:
- 43kDa
- Research Area:
- Cardiovascular; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113917
