CD16 / FcγReceptor III Antibody
Product Sizes
100 ug
£671.00
2214-MSM3-P1ABX-100UG
About this Product
- SKU:
- 2214-MSM3-P1ABX
- Additional Names:
- CD16-II | CD16a antigen | Fc-gamma RIII-alpha | FcR-10 | IgG Fc receptor III-2
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- HuNK2
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes CD16 (FcgammaRIII); the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. Two similar genes represent CD16; CD16A (FcgammaRIIIA); which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcgammaRIIIB); which exist as a monomeric GPI-anchored form in neutrophils. Furthermore; there are two known polymorphisms of CD16B; NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding; both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC); phagocytosis; degranulation and proliferation.
- Host:
- Mouse
- Immunogen:
- Human peripheral blood lymphocytes from a NK-leukemia patient.
- Isotype:
- IgG2a
- Molecular Weight:
- 50-80kDa
- Research Area:
- Cardiovascular; Complement System; Dendritic Cell Marker; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113911
