CD32 (Fc Gamma RIIa) Antibody
Product Sizes
100 ug
£671.00
2212-MSM3-P1ABX-100UG
About this Product
- SKU:
- 2212-MSM3-P1ABX
- Additional Names:
- CDw32 | Fc-gamma RII-a
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- 8.7
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the epitope overlaps with that of MAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis; cytotoxicity; and immunomodulation as well as platelet aggregation. Three genes (A; B; and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing; i.e.; IIa1; IIa2; IIb1; IIb2; IIb3 and IIc. Monocytes/macrophages; placental trophoblasts and endothelial cells express all isoforms. In addition; the IIb isoform is expressed by B cells; and the IIa isoform by platelets; granulocytes and; weakly; by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.
- Host:
- Mouse
- Immunogen:
- K562 and FcgRII+L cells
- Isotype:
- IgG1
- Molecular Weight:
- 40kDa
- Research Area:
- Cardiovascular; Hematopoietic Stem Cells; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113887
