CD64 / Fc gamma RI Antibody
Product Sizes
20 ug
£364.00
2209-MSM3-P0-20UG
About this Product
- SKU:
- 2209-MSM3-P0
- Additional Names:
- Fc-gamma RI | Fc-gamma RIA
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- FCGR1A/7496
- Clonality:
- Monoclonal
- Extra Details:
- Three different classes of IgG Fc receptors have been described: Fc Î � RI (CD64); Fc Î � RII (CD32) and Fc Î � RIII (CD16). The low affinity receptors; CD64 and CD16; have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG; is expressed constitutively on monocytes and macrophages; and can be induced in neutrophils subsequent to IFN-Î � stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far; three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will coimmunoprecipitate with CD64 subsequent to receptor cross linking.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human CD64 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 43kDa
- Research Area:
- Cytokine Signaling; Immunology; Infectious Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127993
