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Antibodies

CD23 (Fc Epsilon RII) Antibody

Product Sizes
100 ug
£671.00
2208-MSM12-P1-100UG
About this Product
SKU:
2208-MSM12-P1
Additional Names:
BLAST-2 | C-type lectin domain family 4 member J | Fc-epsilon-RII | Immunoglobulin E-binding factor | Lymphocyte IgE receptor
Application:
Immunohistochemistry
translate.label.attr.clone:
FCER2/6892
Clonality:
Monoclonal
Extra Details:
CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells; monocytes; eosinophils; platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted; then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells; B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.
Host:
Mouse
Immunogen:
Recombinant fragment (around aa 200-300) of human FCER2/CD23 protein (exact sequence is proprietary)
Isotype:
IgG2b
Molecular Weight:
37kDa (soluble form); 45kDa (membrane-bound form)
Research Area:
B Cell Markers; Complement System; Cytokine Signaling; Immunology; Mast Cell Marker; Signal Transduction
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody