Fibroblast Activation Protein Alpha / FAP-1 Antibody
Product Sizes
20 ug
£364.00
2191-MSM1-P0-20UG
About this Product
- SKU:
- 2191-MSM1-P0
- Additional Names:
- 170 kDa melanoma membrane-bound gelatinase | Dipeptidyl peptidase FAP | Fibroblast activation protein alpha | Gelatine degradation protease FAP | Integral membrane serine protease | Post-proline cleaving enzyme | Serine integral membrane protease | Surface-expressed protease
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- FAP/4851
- Clonality:
- Monoclonal
- Extra Details:
- FAP (fibroblast activation protein) is a cell surface glycoprotein and serine protease that is expressed primarily in fetal mesenchymal tissues and epithelial cancer fibroblasts. In cancer; FAP functions to promote cellular proliferation. In embryonic development; FAP functions to remodel developing tissues. FAP acts as an integral membrane gelatinase composed of N-glycosylated proteolytically inactive subunits. FAP expression on chondrocyte membranes is upregulated by the combination of the cytokines IL-1 and OSM and has been shown to increase in osteoarthritic patients. This expression is colocalized with MMP-1 and MMP-13 as well as CD44 (variants v3 and v7/8). Mice that lack all copies of the FAP gene have been found to be fertile and to have developmental defects or change in cancer susceptibility.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 1-200) of human FAP protein (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- 88kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113822
