Recombinant ETS1 (Marker of Tumor Metastasis) Antibody
Product Sizes
100 ug
£671.00
2113-MSM8-P1ABX-100UG
About this Product
- SKU:
- 2113-MSM8-P1ABX
- Additional Names:
- p54
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- r1G11
- Clonality:
- Monoclonal
- Extra Details:
- The proto-oncogene c-Ets-1 is a transcription factor known to regulate expression of a number of genes involved in extracellular matrix remodelling. The processes of tumor invasion and metastasis are thought to depend on the increased proteolytic activity of the invading tumor cells which may involve matrix metalloproteinases; cathepsins B and D and plasminogen activator in the metastatic cascade. Ets-1 interacts with the urokinase-type plasminogen activator gene enhancer and with the promoters of stromelysins-1 and collagenase-1 gene which may implicate it in this process. In situ hybridisation studies have indicated Ets-1 mRNA to be absent from normal colon mucosa but positive in endothelial cells of stromal capillaries and stromal fibroblasts; often with increased staining in fibroblasts adjacent to neoplastic cells.
- Host:
- Mouse
- Immunogen:
- Prokaryotic recombinant protein corresponding to amino acids 38 to 308 of the human Ets-1 oncoprotein isoform 2
- Isotype:
- IgG1
- Molecular Weight:
- 54kDa
- Research Area:
- Angiogenesis; Cardiovascular; Endothelial Cell Marker; Hypoxia; Nuclear Marker; Ovarian Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=141319
