Recombinant Estrogen Receptor; alpha (Marker of Estrogen Dependence) Antibody
Product Sizes
100 ug
£671.00
2099-RBM43-P1ABX-100UG
About this Product
- SKU:
- 2099-RBM43-P1ABX
- Additional Names:
- ER-alpha | Estradiol receptor | Nuclear receptor subfamily 3 group A member 1
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- ESR1/6983R
- Clonality:
- Monoclonal
- Extra Details:
- Estrogen receptor (ER) belongs to the steroid receptor superfamily of nuclear receptors. It is a protein with 553 amino acids. The receptor molecule has three domains; i.e. the central DNA-binding domain; the hormone-binding domain at the C-terminal; and the transcription-activating domain at the N-terminal. ER mediates regulatory functions of female sex steroids; mainly 17 (E2); on growth; differentiation and function in several target tissues; including female and male reproductive tract; mammary gland; and skeletal and cardiovascular systems. Studies have shown ER 伪 is present in the nuclei of epithelial cells in normal breast and endometrial tissues; as well as a subset of breast carcinomas. Studies with immunohistochemical assay show that positive steroid hormone status has predicted favorable overall; survival; independently of hormonal treatment. Secondly; ER 伪 can be used as a tumor marker; preferentially in combination with an antibody to progesterone receptor; e.g.; in the classification of adenocarcinomas.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa495-595) of human ER alpha protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- ~67kDa
- Research Area:
- Breast Cancer; Cardiovascular; Infectious Disease; Ovarian Cancer; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113588
