Recombinant ERG / ETS Transcription Factor (Prostate Cancer Marker) Antibody
Product Sizes
20 ug
£364.00
2078-RBM7-P0-20UG
About this Product
- SKU:
- 2078-RBM7-P0
- Additional Names:
- Transforming protein ERG
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- ERG/9122R
- Clonality:
- Monoclonal
- Extra Details:
- ERG (ETS-related gene) is a proto-oncogene; a member of the ETS family of transcription factors. The ERG gene encodes for a nuclear protein; also called ERG; which is involved in hematopoietic and endothelial development. ERG remains constitually expressed in endothelial cells in blood and lymphatic vessels; and in bone marrow stem cells. ERG is expressed in virtually all endothelial neoplasms including hemangioendothelioma; angiosarcoma and Kaposi sarcoma. ERG is overexpressed secondary to gene rearrangement in cases of prostate adenocarcinoma; gastrointestinal stromal tumor; synovial sarcoma; meningioma; epithelioid sarcoma; malignant rhabdoid tumor; acute myeloid leukemia and blastic extramedullary myeloid tumor; and rarely Ewing sarcoma / primitive peripheral neuroectodermal tumor; chondrosarcoma; osteosarcoma; and rhabdomyosarcoma. For the identification of endothelial differentiation ERG seems more sensitive and specific than any other marker. Moreover; the interpretation is often easier due to the nuclear reaction; which also allows for double stains with cytoplasmic markers like podoplanin. Among carcinomas; ERG is highly specific for prostate; while the sensitivity is moderate.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa279-479) (C-terminus) of human ERG (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 55kDa
- Research Area:
- Endothelial Cell Marker; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=133102
