Recombinant AKT1 (Prognostic Marker for Neuroendocrine Tumors) Antibody
Product Sizes
100 ug
£671.00
207-MSM5-P1-100UG
About this Product
- SKU:
- 207-MSM5-P1
- Additional Names:
- Protein kinase B | Protein kinase B alpha | Proto-oncogene c-Akt | RAC-PK-alpha
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rAKT1/2491
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 62kDa; which is identified as AKT1The serine/threonine kinase Akt family contains several members; including Akt1 (also designated PKB or RacPK); Akt2 (also designated PKB尾 or RacPK-尾) and Akt 3 (also designated PKB纬 or thymoma viral proto-oncogene 3); which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-尾 tyrosine residues 740 and 751; which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s); and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human AKT1 protein (around aa 85-189) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 62kDa
- Research Area:
- AKT Signaling; BBB VCAM-1 Signaling; Breast Cancer; Cardiovascular; Colon Cancer; Cytokine Signaling; Developmental Biology; Immunology; Infectious Disease; Lung Cancer; MAPK Signaling; Neuroinflammat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113495
