HER-4 / ERBB4 Antibody
Product Sizes
20 ug
£364.00
2066-MSM1-P0-20UG
About this Product
- SKU:
- 2066-MSM1-P0
- Additional Names:
- Proto-oncogene-like protein c-ErbB-4 | Tyrosine kinase-type cell surface receptor HER4 | p180erbB4
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- ERBB4/2581
- Clonality:
- Monoclonal
- Extra Details:
- The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1); Neu (ErbB-2; HER2); ErbB-3 (HER3) and ErbB-4 (HER4); which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein; which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines; normal skeletal muscle; heart; pituitary; brain and cerebellum. Its expression in breast cancer; pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 1116-1269) of human ERBB4 (HER4) protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 180kDa (precursor); 80/120kDa (cleaved)
- Research Area:
- AKT Signaling; Cardiovascular; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113465
