TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer) Antibody
Product Sizes
20 ug
£364.00
201633-MSM3-P0-20UG
About this Product
- SKU:
- 201633-MSM3-P0
- Additional Names:
- V-set and immunoglobulin domain-containing protein 9 | V-set and immunoglobulin domain-containing protein 3
- Application:
- ELISA
- translate.label.attr.clone:
- TIGIT/3033
- Clonality:
- Monoclonal
- Extra Details:
- TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR); causing increased IL10 secretion; decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells; as well as peripheral memory and regulatory CD4+ T cells. At the protein level; it is upregulated following the activation of these cells. Functionally; TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TIGIT protein
- Isotype:
- IgG1
- Molecular Weight:
- 26kDa
- Research Area:
- Hematopoietic Stem Cells; Immune checkpoint; Infectious Disease; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=137845
