TIGIT / VSTM3 / VSIG9 (Immune Checkpoint for Cancer) Antibody

Product Sizes

100 ug

£671.00

201633-MSM2-P1ABX-100UG

About this Product

SKU:: 201633-MSM2-P1ABX
Additional Names:: Homeobox protein NK-3 homolog A
Application:: ELISA
translate.label.attr.clone:: TIGIT/3018
Clonality:: Monoclonal
Extra Details:: TIGIT is a checkpoint inhibitor which binds with high affinity to the poliovirus receptor (PVR); causing increased IL10 secretion; decreased IL12B secretion. TIGIT binding to PVR also causes the suppression of T cell activation by promoting the generation of mature immuno-regulatory dendritic cells. It is expressed at low levels on natural killer (NK) cells; as well as peripheral memory and regulatory CD4+ T cells. At the protein level; it is upregulated following the activation of these cells. Functionally; TIGIT is similar to CTLA4. The ligands for TIGIT include CD155 (signal abrogation) and CD226 (signal stimulation). It has been demonstrated to be upregulated on T cells in many cancers and is an immuno-oncology target for therapy.
Host:: Mouse
Immunogen:: Recombinant fragment (around aa 22-141) of human TIGIT protein (exact sequence is proprietary)
Isotype:: IgG2c
Molecular Weight:: 26kDa
Research Area:: Hematopoietic Stem Cells
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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