Alpha-2-Macroglobulin / A2M Antibody
Product Sizes
100 ug
£671.00
2-MSM16-P1ABX-100UG
About this Product
- SKU:
- 2-MSM16-P1ABX
- Additional Names:
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- A2M/6556
- Clonality:
- Monoclonal
- Extra Details:
- α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially; α-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M; thus enabling it to trap the proteinase and further inhibit its activity. Subsequently; α-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M; which renders TGFβ inactive. α-2M also binds to IL-6 and; thereby; increases the concentration of IL-6 near lymphocytes; hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer s disease (AD); which is consistent with the role of α-2M in mediating the clearance and degradation of A β; the major component of β-Amyloid deposits accumulated during AD.
- Host:
- Mouse
- Immunogen:
- Human recombinant A2M protein fragment (around aa 604-748) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 185kDa
- Research Area:
- Cardiovascular; Complement System
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=129852
