Recombinant EGFR (L858R Mutant Specific) Antibody
Product Sizes
100 ug
£671.00
1956-RBM24-P1-100UG
About this Product
- SKU:
- 1956-RBM24-P1
- Additional Names:
- Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase erbB-1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- GFR/4564R
- Clonality:
- Monoclonal
- Extra Details:
- Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF; TGFA/TGF-alpha; amphiregulin; epigen/EPGN; BTC/betacellulin; epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK; PI3 kinase-AKT; PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16; activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance (By similarity). The antibody is specific expressed on EGFR(L858R) mutated lung cancer.
- Host:
- Rabbit
- Immunogen:
- synthetic peptide corresponding to EGFR residues within aa800-900 of EGF receptor (mutated L858R)
- Isotype:
- IgG
- Molecular Weight:
- 134kDa
- Research Area:
- AKT Signaling; Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Developmental Biology; Infectious Disease; MAPK Signaling; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113252
