EGFR (Epidermal Growth Factor Receptor) Antibody
Product Sizes
100 ug
£671.00
1956-MSM39-P1ABX-100UG
About this Product
- SKU:
- 1956-MSM39-P1ABX
- Additional Names:
- Proto-oncogene c-ErbB-1 | Receptor tyrosine-protein kinase erbB-1
- Application:
- ELISA, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- 225
- Clonality:
- Monoclonal
- Extra Details:
- EGFR (Epidermal growth factor receptor; HER1; ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER /ERbB family of proteins that includes three other receptor tyrosine kinases; ERbB2; ERbB3; ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK; PI3-K - Akt; Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2; leading to activation of the MAPK pathway. Upon receptor activation and signaling; EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover; EGFR overexpression is observed in tumors of the head and neck; brain; bladder; stomach; breast; lung; endometrium; cervix; vulva; ovary; esophagus; stomach and in squamous cell carcinoma.
- Host:
- Mouse
- Immunogen:
- Purified EGFR from A431 cells
- Isotype:
- IgG2b
- Molecular Weight:
- ~170kDa (wild type) and ~145kDa (vIII variant)
- Research Area:
- AKT Signaling; Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Developmental Biology; Infectious Disease; MAPK Signaling; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127844
