AGO3 (Argonaute-3) / eIF2C3 Antibody
Product Sizes
20 ug
£364.00
192669-MSM1-P0-20UG
About this Product
- SKU:
- 192669-MSM1-P0
- Additional Names:
- Argonaute RISC catalytic component 3 | Eukaryotic translation initiation factor 2C 3
- Application:
- ELISA, Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-AGO3-1C5
- Clonality:
- Monoclonal
- Extra Details:
- This antigen is involved in binding and translation repression of short RNAs. This antigen is also known as argonaute RISC catalytic component 3.Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (siRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent siRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human AGO3 protein
- Isotype:
- IgG1
- Molecular Weight:
- 97.36kDa
- Research Area:
- Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113163
