Desmoglein-3 (Squamous Cell Marker) Antibody
Product Sizes
100 ug
£671.00
1830-MSM5-P1ABX-100UG
About this Product
- SKU:
- 1830-MSM5-P1ABX
- Additional Names:
- 130 kDa pemphigus vulgaris antigen | Cadherin family member 6
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- DSG3/1535
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a protein of 130kDa; identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore; DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover; studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
- Host:
- Mouse
- Immunogen:
- Recombinant human DSG3 extracellular protein fragment
- Isotype:
- IgG1
- Molecular Weight:
- 130kDa
- Research Area:
- Apoptosis; Autophagy; Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=113101
