Desmoglein-3 (Squamous Cell Marker) Antibody

Product Sizes

100 ug

£671.00

1830-MSM10-P1ABX-100UG

About this Product

SKU:: 1830-MSM10-P1ABX
Additional Names:: 130 kDa pemphigus vulgaris antigen | Cadherin family member 6
Application:: Immunohistochemistry
translate.label.attr.clone:: DSG3/2840
Clonality:: Monoclonal
Extra Details:: Recognizes a protein of 130kDa; identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore; DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover; studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Host:: Mouse
Immunogen:: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
Isotype:: IgG1
Molecular Weight:: 130kDa
Research Area:: Developmental Biology
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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