Recombinant TdT / DNA Nucleotidylexotransferase (Acute Lymphoblastic Leukemia Marker) Antibody
Product Sizes
20 ug
£431.00
1791-RBM11-P0-20UG
About this Product
- SKU:
- 1791-RBM11-P0
- Additional Names:
- Terminal addition enzyme | Terminal deoxynucleotidyltransferase
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- MSVA-453R
- Clonality:
- Monoclonal
- Extra Details:
- Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically; TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils; lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias; particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 52-192) of human DNTT protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 58kDa
- Research Area:
- B Cell Markers; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=147565
