DNMT3A / DNA Methyltransferase 3 Alpha Antibody
Product Sizes
100 ug
£671.00
1788-MSM1-P1ABX-100UG
About this Product
- SKU:
- 1788-MSM1-P1ABX
- Additional Names:
- Cysteine methyltransferase DNMT3A
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PCRP-DNMT3A-1E2
- Clonality:
- Monoclonal
- Extra Details:
- The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array; containing more than 19;000; full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Sadenosyl-L-methionin
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length DNMT3A protein
- Isotype:
- IgG1
- Molecular Weight:
- 102kDa
- Research Area:
- Cancer; Epigenetics; Hypoxia; Immuno Oncology; Infectious Disease; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=112981
