Recombinant Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy) Antibody
Product Sizes
20 ug
£364.00
1756-RBM10-P0-20UG
About this Product
- SKU:
- 1756-RBM10-P0
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- DMD/8773R
- Clonality:
- Monoclonal
- Extra Details:
- Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix; through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases; has more than 80 exons; produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle; where it is thought to influence calcium ion homeostasis and force transmission.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa1700-2300) of human DMD (exact sequence is proprietary).
- Isotype:
- IgG
- Molecular Weight:
- 427kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130720
